Open AccessProduction and Evaluation of Disintegrant Properties of Microcrystalline Cellulose Derived from SaccharumofficinarumL (Poaceae) in Metronidazole Based Formulation
Author(s) -
Oraeluno J.N.,
Obasi J.C,
Bamigbola E.A,
Joseph B.A
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences and medicine
Language(s) - English
Resource type - Journals
ISSN - 2519-9889
DOI - 10.47760/ijpsm.2021.v06i04.004
Subject(s) - microcrystalline cellulose , friability , cellulose , starch , dissolution , chemistry , materials science , chromatography , chemical engineering , food science , biochemistry , polymer , organic chemistry , ethyl cellulose , engineering
The aim of the study was to produce microcrystalline cellulose from Saccharumofficinarum and to evaluate its use as a disintegrant in metronidazole tablet formulation. Cellulose was produced and characterized. This was followed by a comparative characterization of the tablets formulated by using Saccharumofficinarummicrocrystalline cellulose (SO-MCC), maize starch and crosscarmellose sodium (Ac-di-sol®) as disintegrants. The granules were evaluated for flow properties and the tablet evaluated for hardness, friability, disintegration and dissolution properties. For disintegration studies, the disintegrants disintegrated within 10 minutes in this order: Ac-di-sol® >SO-MCC>Maize starch. All the tablets exhibited high release profile which conformed to British Pharmacopoeia standards. Hence, SO-MCC can be used as an alternative disintegrant in terms of cost and availability.