Open AccessOverview of the Determination of Clonidine Levels in Pharmaceutical Preparations
Author(s) -
Rahma Yuni Safitri,
Roslinda Rasyid,
Regina Andayani,
Harrizul Rivai
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences and medicine
Language(s) - English
Resource type - Journals
ISSN - 2519-9889
DOI - 10.47760/ijpsm.2021.v06i04.002
Subject(s) - clonidine , chromatography , high performance liquid chromatography , chemistry , dosage form , drug , thin layer chromatography , pharmaceutical formulation , pharmacology , medicine , anesthesia
Clonidine is an α2-central agonist class of drugs widely used to treat cardiovascular diseases such as hypertension, heart attacks and help prevent strokes. The quality and safety of a drug preparation can be proven by testing the drug's quality assurance. In drug quality assurance, it is necessary to determine drug levels. Therefore, it is essential to look at the determination of clonidine levels in raw materials, mixtures, and pharmaceutical preparations. It is collecting data in this review article through trusted sites such as Google Scholar with the search keywords "clonidine hydrochloride," "clonidine analysis in pharmaceutical preparations" with a span of the last ten years (2010-2020). This review article aims to provide an overview of the various analytical techniques used to determine clonidine both in single substance form and in the pharmaceutical dosage form. Several analytical methods, such as UV-Visible spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC), have been reported to determine clonidine in the form of raw materials, mixtures, and pharmaceutical preparations. Overall, the determination of clonidine levels has been carried out by various analytical methods, including spectrophotometry, potentiometry, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC). Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentration. The HPLC-MS method has unique advantages and sensitivity in the analysis of clonidine in pharmaceutical preparations.