Open AccessReview on the Systemic Damage and Biochemical Alterations Associated with COVID-19 Infection
Author(s) -
Yiglet Mebrat
Publication year - 2021
Publication title -
cognizance journal
Language(s) - English
Resource type - Journals
ISSN - 0976-7797
DOI - 10.47760/cognizance.2021.v01i08.003
Subject(s) - neutrophilia , leukocytosis , medicine , procalcitonin , disease , cytokine storm , immunology , pathophysiology , systemic inflammatory response syndrome , systemic inflammation , coronavirus , sepsis , covid-19 , intensive care medicine , inflammation , infectious disease (medical specialty)
According to the WHO daily report, the world lost 4.3 million peoples and more than 203 million of the people were infected by the epidemic till August 10, 2021. Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is a respiratory disease and it is a systemic infection with cardiovascular, pulmonary, gastrointestinal, neurological, and hematological manifestations, leading to death. Many biomarkers reflecting the main pathophysiological characteristics of the disease have been associated with the risk of developing severe disease. Biochemical changes like leukocytosis, neutrophilia, lymphopenia, cytokine storm, decreased albumin, increase in ALT, total bilirubin, LDH, and procalcitonin levels are significant predictors of ICU admitted COVID-19 patients. So, monitoring of biochemical parameters in COVID-19 patients is critical for assessing disease severity and progression as well as monitoring therapeutic intervention.