Open AccessReason of Being of Mast Cells a Hypothesis
Author(s) -
Klas Norrby
Publication year - 2021
Publication title -
annals of vascular medicine and research
Language(s) - English
Resource type - Journals
ISSN - 2378-9344
DOI - 10.47739/vascularmedicine.1136
Subject(s) - inflammation , decidua , angiogenesis , wound healing , extracellular matrix , placenta , immune system , innate immune system , biology , mediator , immunology , uterus , fetus , mast cell , pathological , tissue remodeling , microbiology and biotechnology , medicine , pregnancy , pathology , cancer research , endocrinology , genetics
Mast cells (MCs) have a unique role among the innate immune cells because of their unique and extensive mediator profile and their ability to interact with the vasculature. The physiological role of MCs is unclear. We argue that MCs exist in all species with a circulatory system due to the basic triad tissue response that they are able to produce under physiological and pathological conditions alike: extracellular matrix degradation and tissue remodeling, de novo cell proliferation, and de novo angiogenesis. MC-activation occurs not only in life-saving reactions such as inflammation and wound healing but in implantation, the decidua, the placenta, the pregnant uterus, and the fetus too. In fact, MCactivation is essential for successful pregnancy, and helpful for the survival of the newborn up to reproductive age (owing to beneficial actions of the MCs in inflammation and wound healing), and essential as for reproductive capability in adulthood.