Open AccessClinical, laboratory and molecular-genetic markers of the progression of non-alcoholic fatty liver disease (literature review and own data)
Author(s) -
А. А. Хамраев,
Д.Х Юлдашева
Publication year - 2021
Publication title -
society and innovations
Language(s) - English
Resource type - Journals
ISSN - 2181-1415
DOI - 10.47689/2181-1415-vol2-iss2/s-pp399-406
Subject(s) - steatohepatitis , fatty liver , hepatology , disease , hepatocellular carcinoma , medicine , fibrosis , epidemiology , gastroenterology , bioinformatics , biology
Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in hepatology. First of all, this is associated with a high risk of progression of NAFLD with the development of non-alcoholic steatohepatitis (NASH), liver failure, and hepatocellular carcinoma. Epidemiological and genetic studies have shown the relationship between the morphological stage of NAFLD and hereditary factors. The article provides a review of the literature on the cytokines, MBOAT7 and GCKR genes. Also, a variant of the MBOAT7 and GCKR gene is associated with a high risk of fibrosis in patients with NAFLD and elevated serum triglyceride levels.