Study About Alzheimer’s Disease and Their Management by Using Antioxidants

Alzheimer is a neurodegenerative disease caused by neuronal cell death, and it is the most common type of dementia which produces progressive impairment of behavioral ad cognitive functions including memory, language, attention, judgment and reasoning. In the United States they are the sixth leading cause of death. Depend upon the stages of Alzheimer the symptoms will be exposed. It typically begins from the entorhinal cortex in the hippocampus. For increase the risk of Alzheimer Disease by Traumatic head injury, depression, cerebro vascular disease, family history of dementia and also presence of APOE e4 allele. By the report of global prevalence of dementia to be high as 24 million, and it is increased 4 times by the year 2050. In the United States estimated health care amount for Alzheimer disease is $172 billion per year. Multiple factors cause AD by genetics, environmental factors, and general lifestyles and also senile plagues and intracellular neurofibrillary tangles are the pathology of Alzheimer. In this review, I focus that stress is an important phenomenon for correlates with free radicals and antioxidant in organism that is due to an oxidative Stress imbalance between free radicals and antioxidant production of reactive oxygen and nitrogen species will be increased. That oxidative stress plays on very essential role in stimulating and activating multiple cells signaling cause lesion formation of toxic substance cause promotes to develop AD.