Open AccessAnimal Models of Hyperlipidemia: An Overview
Author(s) -
Sambhav Lodha,
Jagdish Kakadiya
Publication year - 2022
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2022.v72i02.023
Subject(s) - in vivo , hyperlipidemia , animal model , in vitro , animal studies , experimental animal , transgene , genetically modified mouse , animal testing , pharmacology , medicine , biology , biochemistry , endocrinology , microbiology and biotechnology , diabetes mellitus , gene , veterinary medicine , ecology
Several frequently used animal models of atherosclerosis are described in this mini review. Rats, Mice, rabbits, pigs, and non-human primates have been highlighted among them. Despite the fact that these animal models have helped us understand how atherosclerotic lesions form, we still don't have a suitable animal model for disease reversal. The present technique for screening method for antihyperlipidemic activity could be classified under in vitro and in vivo methods. In vivo methods include Triton, PTU-, Fructose & high fat diet induced hyperlipidemic models. In vitro methods include In vitro Assay using Caco-2 Cell Lines and Inhibition of HMG CoA Reductase. Several genetically modified and transgenic animal models that mimic human atherosclerosis have been described by researchers, although each of the existing animal models has certain drawbacks. The features of animal models utilized in atherosclerosis research are described in this review study.