Open AccessEvaluation of Analgesic Effect of Apigenin in Rodent
Author(s) -
Arka Mondal,
Harihar Dikshit,
Lalit Mohan,
Manish Kumar,
Margoob Ahmad,
M. Nagaraj Kumar,
Dr.Hitesh Mishra
Publication year - 2022
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2022.v72i01.021
Subject(s) - apigenin , analgesic , medicine , tramadol , pharmacology , osteoarthritis , rheumatoid arthritis , drug , flavonoid , anesthesia , chemistry , biochemistry , alternative medicine , pathology , antioxidant
In Chronic inflammatory and painful diseases, such as Osteoarthritis, Rheumatoid arthritis, Low back pain, Fibromyalgia drugs thatare currently used for the treatment of pain are opioids and for inflammatory conditions are non-steroidal anti-inflammatory drugs(NSAIDs) and corticosteroids. All these drugs produce potential toxic effects. Apigenin, a naturally occurring plant flavone, abundantlypresent in common fruits and vegetables, is recognized as a bioactive flavonoid. Current study envisaged analgesic properties ofapigenin in animal models. Three dose, 10mg/kg,20mg/kg and 40mg/kg of apigenin were used in this study. Analgesic activity wasstudied in rat and mice by radiant tail-flick and Eddys hot plate models respectively. In both models the standard drug used wasTramadol-25mg/kg. The optimal analgesic effect of apigenin can be seen at dose 20mg/Kg in tail-flick(P<0.05) and Eddy’s Hot platemodel (P<0.05) in comparison to control and standard drug respectably. In conclusion Apigenin processes analgesic activities.