Open AccessSynthesis and Characterization of Pamam Dendrimers Loaded with Anti-Viral Drug Amantadine
Author(s) -
P. Arshad,
Dinesh Kumar Dr.P.
Publication year - 2022
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2022.v72i01.014
Subject(s) - dendrimer , pegylation , chemistry , amantadine , polyethylene glycol , drug delivery , in vivo , drug , pharmacology , organic chemistry , medicine , microbiology and biotechnology , biology
The aim of the present study is to develop and explore efficiency of 5.0G EDA PAMAM dendrimers as long-duration drug releasecarriers and reduce the hemolytic toxicity of the drug for the treatment of virus. Amantadine (AMD) was selected as a major drug forincorporation into PAMAM dendrimers based on its anti-viral activity and hydrophobic nature. Further polyethylene glycol(PEGylated) PAMAM dendrimers were evaluated for their hemolytic toxicity and in vivo anti -viral studies. The 5.0G PAMAMdendrimers are prepared by using initiator core ethylene diamine and methyl acrylate. Furthermore, the PEGylation was done bypolyethylene glycol600 using epichlorhydrin as a cross linking agent. The Amantadine loaded PEGylated 5.0G PAMAM dendrimerswere characterized by FTIR and SEM analysis. The in vivo study report ensures the suitability of PEGylated dendrimer in connectionto prolonged delivery of Amantadine. Moreover, PEGylated system has shown a reduced hemolytic toxicity.