Validation of Developed Analytical Methods for the Determination of Remoglifozin and Ertuglifozin in Pharmaceutical Dosage Forms - An Updated Review

SGLT is the newly developed class of antidiabetic medicine also called as gliflozins. Remoglifozin and Ertuflifozin are the SGLT-2 classinhibitors for the treatment of type II diabetes mellitus. The aim of this review is to focus on update of determination of Remogliflozinand Ertuglifozin in bulk and in pharmaceutical dosage forms using chromatographic and spectrophotometric methods. Remogliflozinand Ertuglifozin is estimated by RP-HPLC, UV, RP-UPLC, LC-MS methods. There are plenty of articles which have already beenpublished describing analytical methods and method validation for the same. In present review account, the disclosed analyticalmethods are outlined for the establishment of Remoglifozin and Ertuflifozin in its pharmaceutical preparations and biologicalmatrices. Most frequently used techniques such as spectrometric and liquid chromatographic methods are summarized in presentreview. Spectrometric methods for Remoglifozin and Ertuflifozin alone and in combination include parameters like ? max, solvent,matrix etc. and HPLC methods for Remoglifozin and Ertuflifozin alone and in combination including parameters like matrix, stationaryphase, mobile phase composition detection wavelength etc. HPTLC methods including parameters like stationary phase, mobile phasecombination, RF etc. This review also provides detailed information on separation conditions for Remogliflozin and Ertuglifozin alone,in the presence combination with other drugs and in presence of its degradation products.