Open AccessStealth Liposomes in Human Welfare: An Overview
Author(s) -
V Ashok,
Padmini PJ
Publication year - 2022
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2022.v72i01.003
Subject(s) - liposome , polyethylene glycol , vesicle , chemistry , bilayer , drug carrier , drug delivery , lipid bilayer , drug , biophysics , nanotechnology , pharmacology , materials science , membrane , biochemistry , medicine , biology
Liposomes are artificially made vesicles which has a lipid bilayer and can be used as a drug carrier molecule for the treatment ofvarious cancers and other diseases. Conventional liposomes have short half-life because of rapid uptake by reticuloendothelial systemwhich leads to decrease in the concentration of liposomes and drug efficacy. Liposomes when coated with polyethylene glycol leadsto decreased uptake by the macrophages. This is called as stealth effect which prolongs the half-life of liposome in the circulation andin turn improves drug effectiveness. The liposomes coated with polyethylene glycol are also called as sterically stabilized liposomesor stealth liposomes. This review focuses on the characteristics, methods of preparation, applications, advantages and limitations ofstealth liposomes.