Open AccessCurcumin (Curcuma longa): An Ecofriendly and Ayurvedic Antiproliferative Agent to Control Human Breast Cancer and Prostate Cancer
Author(s) -
Anitha Joicea,
J. Manju Bashini,
Dilla Jose,
Parvesh Kumar,
Ettiappan Munuswamy,
Dhurairaj Satheesh
Publication year - 2022
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2022.v72i01.001
Subject(s) - curcumin , cancer , curcuma , metastasis , angiogenesis , proliferating cell nuclear antigen , cancer cell , cancer research , cell growth , apoptosis , cell cycle , prostate cancer , melanoma , biology , medicine , pharmacology , traditional medicine , biochemistry
Curcumin, a strong anti-cancer ingredient that is found in turmeric and curry, is a prominent yellow pigment and spice. Curcumin'santi-tumour properties include inhibition of tumour proliferation, angiogenesis, invasion, and metastasis, induction of tumourapoptosis, increased chemotherapy sensitivity, and cell cycle and cancer stem cell regulation, suggesting that curcumin has a strongtherapeutic potential of modulating cancer progression. Curcumin's anticancer impact has been demonstrated in human breastcancer cell lines and human prostate cancer cell lines using the Proliferating Cell Nuclear Antigen (PCNA) assay and colony formationtest, respectively. Curcumin was employed at various concentrations (1, 5, 10, 25, 50, and 100 g/ml). Curcumin inhibits cancer cellgrowth in the PCNA assay, and colonies were stained with crystal violet and the number of clones in a particular region was countedfor each condition in the colony forming study. Higher concentrations of curcumin were found to be effective against cancer cell lines in this investigation.