Open AccessA Comparative Review of Preclinical Infertility Models
Author(s) -
Kavitha Andugula,
Narendra Babu Ankem
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i02.022
Subject(s) - infertility , menopause , estrous cycle , medicine , animal model , physiology , androgen , rodent model , fertility , gynecology , hormone , biology , pregnancy , population , genetics , environmental health
Current animal models of infertility in female rats fail to adequately recapitulate transitions like fluctuations in hormonal changes andother complications. androgen-induced infertility rodent model is cause PCO and a new rodent model of Accelerated ovarian failure(AOF) successfully replicate the human perimenopause and postmenopause also it including estrus acyclicity and undetectableestrogen levels .This models not only for menopause it is also useful method for various other infertility models, to develop this modelvarious chemicals are used but in that all models 4- Vinyl cyclohexene diepoxide (VCD) novel chemical which is used for induction ofmenopause in female rodents. Along with menopause it can also used for other infertility and gynecological complications. In thisstudy other infertility models were compared with androgen induced infertility rodent model, VCD model and our aim to use thisanimal models to elucidate novel perspective and interventions for maintaining a high quality of life in women and to potentiallydecrease the negative health consequences associated with these changes during age and other gynecological, neurologicalcomplications.