Open AccessEffect of Chloramphenicol on Reproductive Function in Female Wistar Rats
Author(s) -
Oyedeji K.O,
Okunlola D.O,
Oderinde Gbenga
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i02.020
Subject(s) - estrous cycle , chloramphenicol , endocrinology , biology , medicine , reproductive cycle , ovary , andrology , lumen (anatomy) , reproduction , physiology , antibiotics , ecology , microbiology and biotechnology
This study was designed to investigate the effect of chloramphenicol on reproductive function in female Wistar rats. Fifteen femalerats (120 – 160 g) were used for the estrous cycle and histopathological studies. Chloramphenicol (7.14 mg/kg) was administeredorally on daily basis for 21 and 50 days respectively for the estrous cycle and histological studies. Estrous cycle was carried out usingthe technique of Marcondes et al., histologies of the ovaries and uteri were also carried out. Data were analysed using descriptivestatistics and student’s t-test at p=0.05. Treatment of rats for 21 days with chloramphenicol (7.14 mg/kg) produced significant(p<0.05) reductions in the proestrous and diestrous phases as well as a significant (p<0.05) increment in the estrous phase of theestrous cycle relative to their respective controls. The histopathological study presented with no visible lesions on the ovaries anduteri, but few endometrial glands have expanded lumen. It can therefore be concluded that chloramphenicol probably has pro-fertilityas well as exhibits non-deleterious effects on the reproductive tissues of female Wistar rats.