Open AccessEffect of Organogelator Concentration on Gelation Kinetics and Drug Release Behaviour of Paracetamol-Loaded Soybean Oleogels
Author(s) -
Dipanjana Ash,
Sutapa Biswas Majee,
Gopa Roy Biswas
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i02.013
Subject(s) - kinetics , chemistry , diffusion , solvent , dissolution , chemical engineering , chromatography , organic chemistry , thermodynamics , physics , quantum mechanics , engineering
Organogelators induce 3-D networked structures in apolar solvent molecules via cross-linking of non-covalent self-assembledaggregates below the gelation temperature. The objective of the present investigation was to evaluate the effects of different Span40 concentrations on gelation kinetics and drug release behaviour of topical soybean oleogels. An inversely proportional relationshipwas observed between gelation time, melt flow index and concentration of Span 40 in soybean oleogels. Gompertz model wasemployed on gelation kinetics data to determine organogelator and oil parameters which are assumed to be associated with thermalstability and gel flexibility respectively. Formulation OGS2 (18% W/V Span 40) formed less viscous, thermally stable and presumablymore flexible oleogel compared to other formulations. Nearly ideal zero-order release of paracetamol was achieved from OGS*2following Fickian diffusion. However, slow drug release profiles, higher t50 values were observed with oleogels having 20-24% w/vSpan 40 which followed Korsmeyer-Peppas kinetics with non-Fickian diffusion.