Open AccessEffect of Clindamycin on Reproductive Function in Female Wistar Rats
Author(s) -
Oyedeji K.O,
Okunlola D.O,
Zachariah Richard
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i02.007
Subject(s) - estrous cycle , ovary , endocrinology , andrology , medicine , biology , physiology
This study was designed to investigate the effect of clindamycin on reproductive function in female Wistar rats. Fifteen female rats(120 – 160 g) were used for the estrous cycle and histopathological studies. Clindamycin (8.57 mg/kg) was administered orally ondaily basis for 21 and 50 days respectively for the estrous cycle and histological studies. Estrous cycle was carried out using thetechnique of Marcondes et al., histologies of the ovaries and uteri were also carried out. Data were analysed using descriptivestatistics and student’s t-test at p=0.05. Treatment of rats for 21 days with clindamycin (8.57 mg/kg) produced significant (p<0.05)reductions in the proestrous and diestrous phases as well as significant (p<0.05) increments in the estrous and metestrous phases ofthe estrous cycle relative to their respective controls. The histopathological study presented with no deleterious effects on the ovarianand uterine tissues in the rats. It can therefore be concluded that clindamycin probably has pro-fertility effect without deleteriouseffects on the ovaries and uteri at histological level in female Wistar rats.