Open AccessIn vivo Evaluation of Theophylline Sustained Release Matrix Tablets Containing Low Viscosity Guar Gum
Author(s) -
Tadikonda Rama Rao,
Satyanarayana Sreemantula
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i02.006
Subject(s) - theophylline , guar gum , bioavailability , chemistry , guar , in vivo , pharmacology , cmax , absorption (acoustics) , matrix (chemical analysis) , chromatography , materials science , food science , medicine , microbiology and biotechnology , biology , composite material
The present investigation was carried out to evaluate the utility of guar gum as a hydrophilic matrix carrier in the design of oralcontrolled drug delivery. Based on the earlier reports, the low viscosity guar gum appears to be superior to medium and high viscositygrades of guar gum in providing a sustained delivery of theophylline along the GI tract. Conducting in vivo studies on theophyllinematrix tablets containing 10% of low viscosity guar gum as a representative formulation assessed the in vivo performance of the guargum matrix tablets. The in vivo studies were carried out in dogs. The effective concentration of theophylline was sustained for aperiod of 16 hours. The extended tmax, reduced absorption rate constant, prolonged MRT, unchanged Cmax and unchangedbioavailability indicate a controlled release of theophylline from the guar gum matrix tablets resulting in a sustained absorption andprolonged blood levels of theophylline. The theophylline matrix tablets showed blood levels well below 15 ?g/mL indicating freedomfrom adverse effects. Based on the studies, guar gum appears to be a potential carrier in the design of oral controlled drug deliverysystems.