Open AccessFormulation and Evaluation of Nanosuspension as an Alternative Approach for Solubility Enhancement of Simvastatin
Author(s) -
Mohini E. Shinde,
Mitesh P. Sonawane,
Avish D. Maru
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i01.012
Subject(s) - solubility , bioavailability , pulmonary surfactant , particle size , simvastatin , dissolution , chromatography , materials science , saturation (graph theory) , chemistry , chemical engineering , organic chemistry , pharmacology , mathematics , medicine , biochemistry , combinatorics , engineering
Solubility is an essential factor for drug effectiveness. Simvastatin is poorly water-soluble drug and its bioavailability is very low.Nanosuspension is one of those approach which can tremendously enhance the effective surface area of drug particles by reducingthe particle size and there by increases the rate of dissolution and hence improve bioavailability. The main purpose of the presentinvestigation was to increase the saturation solubility of simvastatin by preparation of nanosuspension. Nanosuspension ofsimvastatin were prepared by nanoprecipitation method using hydroxypropyl cellulose as stabilizer and sodium lauryl sulphate assurfactant. Prepared nanosuspension was evaluated for its particle size, total drug content, entrapment efficiency and saturationsolubility study. On the basis of the evaluation, the best batch F8 formulation demonstrated highest drug content and entrapmentefficiency with average particle size of 0.004µm. The saturation solubility studies show the solubility of the prepared nanosuspensionhas increased as compared to the pure drug due to the particle size reduction. The nanosuspension of simvastatin could besuccessfully prepared and can be concluded that the nanosuspension formulation is a promising approach to enhance the solubility.The nanoprecipitation is a simple and effective method to produce nano sized particles of poorly water-soluble drugs with enhancesolubility.