Open AccessCytotoxic Activity of Zinc Oxide Nanoparticles Using Zingiber officinale Rhizome Extracts Against Leukemia (K562) Cell Line
Author(s) -
Sayantani Pal,
Tapas Pal,
Shila Elizabeth Besra
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v71i01.010
Subject(s) - chronic myelogenous leukemia , k562 cells , mtt assay , zingiber officinale , fourier transform infrared spectroscopy , nanoparticle , zinc , cytotoxicity , chemistry , absorbance , nuclear chemistry , leukemia , in vitro , biochemistry , materials science , chromatography , biology , traditional medicine , nanotechnology , medicine , immunology , organic chemistry , physics , quantum mechanics
Zinc Oxide (ZnO) nanoparticle was synthesized using rhizome extracts of Zingiber officinale for in-vitro anti-cancer study. Thecharacterization of nanoparticle was confirmed using ultraviolet spectroscopy and Fourier Transfer Infrared Spectroscopy (FTIR). TheZGNPE characterization also used the UV-Vis Spectrophotometer spectrum technique to measure the structural characterization ofnanoparticles by determine the absorbance measurement. Cytotoxic activity of myelogenous leukemia cells (K562) and normalhuman embryonic Kidney (HEK293T) cells were performed by MTT assay. Treated with ZnO nanoparticle with Zingiber officinaleextracts (ZGNPE) showed significant inhibition on the cancer cells whereas in normal cell showed insignificant toxicity. Thus, ZGNPEmay be used as chemotherapy drug and an enormous medical application with less toxicity in future. Further mechanistic studies are in progress.