Open AccessPreparation and Evaluation of a Novel Oral Microemulsion Drug Delivery System for Enhancing the Bioavailability of Diltiazem
Author(s) -
Ranajit Nath,
Ratul Bhowmik,
Rajarshi Chakraborty,
Sourav Datta,
Apala Chakraborty
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i02.019
Subject(s) - bioavailability , microemulsion , diltiazem , chemistry , drug delivery , drug , chromatography , solubility , pharmacology , calcium , pulmonary surfactant , medicine , organic chemistry , biochemistry
Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explorethe benefits of microemulsion formulation as an oral drug delivery system for immediate release to improve the bioavailability andefficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The optimizedformulation was evaluated for physicochemical parameters like viscosity, pH, conductivity, and accelerated stability studies. In vitrorelease, diltiazem microemulsion was investigated.