Open AccessPreparation and Evaluation of Topical Microemulsion System Containing Metronidazole
Author(s) -
Rajarshi Chakraborty,
Ratul Bhowmik,
Ranajit Nath,
Sourav Datta,
Apala Chakraborty
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i02.017
Subject(s) - isopropyl myristate , microemulsion , metronidazole , pulmonary surfactant , chemistry , solubility , bioavailability , chromatography , distilled water , dosage form , dissolution , aqueous solution , nitroimidazole , organic chemistry , pharmacology , antibiotics , medicine , biochemistry
Metronidazole is a synthetic nitroimidazole derived with antimicrobial and anti-inflammatory properties. The aqueous solubility ofthis drug is poor which results from low bioavailability. Limited effects on the removal of bacteria are shown in the local administrationof plain metronidazole. The microemulsion system proves the efficacy of solubility and dissolution improvement of poorly watersoluble drugs such as metronidazole. The objective of this project work is to prepare and evaluate metronidazole containing topicalwater-in-oil microemulsion and to compare its effectiveness to other commercially available products. In this formulation, tween 80is used as a surfactant and PEG 400 is used as a co-surfactant. In the oil phase, isopropyl myristate is used. Distilled water is used asthe hydrophilic phase. The formulation of metronidazole containing microemulsion was evaluated for physicochemical parameterslike pH, viscosity, conductivity, accelerated stability studies. In vitro release study was also performed to evaluate the release kinetics.