Open AccessA Retroprospective Study of an Antimicrobial Stewardship Program on Antimicrobial Utilization at a Tertiary Care Medical Center in Kolkata
Author(s) -
Sujay Ranjan Deb,
Sourav Maiti,
Arpan Dutta Roy,
Prolay Paul,
Dipankar Maiti,
Triyasha Adhikary
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i02.013
Subject(s) - antibiotics , medicine , meropenem , defined daily dose , linezolid , antimicrobial stewardship , formulary , dosing , antimicrobial , teicoplanin , antibiotic stewardship , colistin , population , pediatrics , intensive care medicine , antibiotic resistance , vancomycin , family medicine , pharmacology , medical prescription , environmental health , biology , microbiology and biotechnology , genetics , bacteria , staphylococcus aureus
The WHO has set Defined Daily Dose which represent the average daily dose of an antibiotic in a standard patient. The DDD mainlyfocuses on population-based parameters & assumes that patients as well as hospitals are homogenous entities. DOTs are very usefulin order to classify antibiotic days based on patient-level exposure. DOTs merely mean the number of days that a patient is on anantibiotic, irrespective of dose. DOTs signifies that the underlying assumptions about antibiotic dosing was appropriate. Additionally,when patients receive more than one antibiotic, supplementary DOT may be counted. The 300-bed tertiary care medical center servesadults and paediatrics. An all-time Microbiology Consultant and a Clinical Pharmacology trainee used to go for round daily and usedto collect data for ASP for the period of 3 months that is April to June,2021. In this study we have compared DOT of some importantantibiotics for a specific period of time for both COVID and NON COVID patient. ASP-focused antibiotics were antibiotics routinelyevaluated by the ASP team for appropriateness during therapy and the potential to optimize their appropriate use through policies,protocols, formulary restrictions, or clinician education. ASP-focused antibiotics included meropenem, linezolid, pip-taz, poly b,colistin, teicoplanin. In this study we have compared the DDD for 2 specific period of time for better understanding the consumptionof those antibiotics. In conclusion, following the initiation of an ASP, significant decreases in utilization, increases in cost savingsoccurred. In our study we have reduced the consumption and DDD of linezolid which is clinically significant. When it comes to DOTs;We have reduced the DOTs of piptaz and teicoplanin for covid patient And Reduced the DOTs of meropenem and teicoplanin for noncovid patient which is clinically and statistically significant.