Open AccessEvaluation of Polyherbal Formulation (Kemite) on Cafeteria Diet-induced Obesity in Wistar Rats
Author(s) -
Gnangoran Boua Narcisse,
Traoré Moussa,
Yapo Angoué Paul
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i01.020
Subject(s) - cafeteria , obesity , very low density lipoprotein , medicine , cholesterol , body weight , endocrinology , lipid profile , lipoprotein , pathology
Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. This pathology is a real public healthproblem. The work was undertaken to evaluate the antiobesity efficacy of aqueous extract of Kemite in cafeteria diet induced obeseWistar rats for a period of 28 days. Aqueous extract of Kemite (AEK) was prepared by hot extraction method. Female Wistar ratsweighing 124-170 g were divided into different groups i.e. Normal control, cafeteria control and aqueous extract of Kemite at doseof 200 mg/kg bw. The antiobesity activity is estimated in terms of body weight gain, food intake, serum triglycerides (TG), Totalcholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), VLDL cholesterol (VLDL-C), blood glucose (BG), ASAT and ALATactivities, atherogenic index, coronary risk index and liver and fat pad weights. Results showed Cafeteria diet fed rats for 28 successivedays significantly increased the body weight, food intake, ASAT and ALAT activities, liver and fat pad weights, atherogenic index,coronary risk index TG, TC, LDL, VLDL, BG and not influenced HDL levels. Rats treated with extract for 28 successive days along withcafeteria diet reversed the effects induced by cafeteria diet. In conclusion, this study revealed that AEK may be a natural and saferemedy for the prevention and control of obesity.