Open AccessA Literature Review on Self Nanoemulsifying Drug Delivery System (SNEDDS)
Author(s) -
D Saikumar,
Leela Prasanna J
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i01.011
Subject(s) - bioavailability , drug delivery , solubility , biopharmaceutical , drug , chemistry , pulmonary surfactant , pharmaceutics , emulsion , chromatography , pharmacology , organic chemistry , medicine , biochemistry , biology , genetics
The Lipid-based drug delivery system is extensively reported within the literature for the enhancing drug solubility, permeability, andbioavailability. A considerable majority of novel pharmacologically active constituents produced in recent drug discovery programsare lipophilic and poorly soluble, posing a significant problem for pharmaceutical researchers enhancing the oral bioavailability ofsuch drug molecules. Self-nano emulsifying drug delivery systems (SNEDDS), are the viable oil-based approaches for drugs that exhibitlow dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, researchers have been focusing on the challengesof BCS Class II and Class IV Drugs for enhancing water Solubility of poorly water-soluble drugs. SNEDDS is a Validate method forenhancing the solubility and bioavailability of lipophilic compounds. It’s the isotropic mixture of oil, surfactant, co-surfactantmolecules and it also containing co-solvent molecule. which spontaneously form oil-in-water nano emulsion of approximately 200nm or less in size upon dilution with water under gentle stirring. It’s Drug delivery system Which possess thermodynamically andkinetically stability. The physicochemical properties, drug solubilization capacity considerably regulates the selection of the SNEDDScomponents. The compositions of the SNEDDS are often optimized with the assistance of phase diagrams. Further to optimize SNEDDScan be done with the help of statistical experimental design. It’s a Novel drug delivery system which is applicable for the parenteral,Ophthalmic, intranasal and cosmetic drug delivery system. And therefore, the present review describes Preparation, components,mechanism of self-Nano emulsification, biopharmaceutical aspects, characterization methods and applications of Selfnanoemulsifying drug delivery system (SNEDDS).