Open AccessDidymocarpus Pedicellate: Bioactive Constituent, Their Molecular Target in Diabetes Mellitus
Author(s) -
Yogeshwary M. Bhongade,
Maheshwari M. Bhongade,
Shubham N. Gharat
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v70i01.004
Subject(s) - diabetes mellitus , aldose reductase , medicine , type 2 diabetes mellitus , traditional medicine , insulin resistance , pharmacology , drug , medicinal plants , flavonoid , type 2 diabetes , antioxidant , bioinformatics , endocrinology , biochemistry , chemistry , biology
Didymocarpus pedicellata (Family: Gesneriaceae), is an herbal drug traditionally used in renal disorders mainly as antiurolithiatic anddo not have much data on this plant, is selected for study and hereby reviewed. This review is based on compilation of data from thevarious researchers on their research work and other data including anti-diabetic activity of Didymocarpus pedicellata and antioxidantactivity in relation with the type 2 diabetes mellitus and its cardiovascular complications. By using various scientific studies, theevidence has been demonstrated as to the antidiabetic effect of the various extract of Didymocarpus pedicellata as well as its chemicalconstituents including various flavonoid like chalcones which are major bioactive constituents chiefly present in Didymocarpuspedicellata. The chalcones present in these plants have various therapeutic targets for the management of type 2 diabetes like PPARg, DPP-4, a-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity. The Didymocarpus pedicellatahas also been reported to exhibit antispasmolytic, antimalarial activity and nephroprotective activity. On the basis of given evidence,it may be concluded that Didymocarpus pedicellata could be the potential target for the treatment of type 2 diabetes mellitus andcan reduce the cardiovascular complication associated with diabetes mellitus.