Open AccessQuality by Design: A Methodical Approach in Development of Nano Delivery System
Author(s) -
Priya S. Milmile,
Rasika J. Patil,
M Samiksha,
Kamlesh Wadher,
Milind J. Umekar
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i02.033
Subject(s) - quality by design , drug delivery , solid lipid nanoparticle , risk analysis (engineering) , computer science , process (computing) , critical quality attributes , quality (philosophy) , nanotechnology , process engineering , biochemical engineering , systems engineering , manufacturing engineering , new product development , process management , engineering , materials science , medicine , business , philosophy , epistemology , marketing , operating system
Pharmaceutical quality by design (QbD) is a methodical approach to development of drug which begins with predefined objectivesand control based on scientific acumen and quality risk management. QbD in the field of pharmacy is based on the basic understandingof the quality profile of final products affects by materials and process parameters. The application of QbD in designing of drug deliverysystem is based on a sound understanding of the sources of variability and the manufacture process and parameters. Most ofproblems in quality in formulations are related to the way designing of pharmaceutical product was carried out. The most importantelement of QbD based drug delivery development is the risk assessment (RA) activity which is important aspect during thedevelopment process. This review article addressed various concepts and applications od QbD to optimize and develop various nanodrug delivery systems such as, examples liposomes, proliposome, nanoliposomes, polymeric nanoparticles, microsponges, solid lipidnanoparticles, transgel. nanostructured lipid carriers, nano emulsions with the research published in recent years.