Open AccessDissolution Enhancement of Flurbiprofen by Solid Dispersion Adsorbate Technique
Author(s) -
Sohansinh Vaghela,
Samkit M. Shah,
Sanjesh G. Rathi,
Shrenik K. Shah
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i02.014
Subject(s) - flurbiprofen , solubility , dispersion (optics) , dissolution , poloxamer , chemical engineering , chemistry , fourier transform infrared spectroscopy , materials science , amorphous solid , polymer , dissolution testing , chromatography , nuclear chemistry , analytical chemistry (journal) , organic chemistry , copolymer , biopharmaceutics classification system , medicine , physics , optics , pharmacology , engineering
Flurbiprofen solid dispersion Adsorbate (SDA) has been prepared using PEG 4000 and Poloxamer 188 as carrier and Neusilin asadsorbent material. The SDA of Flurbiprofen was prepared by using Fusion method in various drugs to carrier ratios. The phasesolubility study concludes that both polymers have ability to improve the aqueous solubility of flurbiprofen. Pure API Flurbiprofen and final formulation samples of SDA are characterized by FTIR, DSC and X-ray diffraction spectroscopy. X-ray powder diffraction and DSC study indicated that the drug was present in amorphous form. FTIR study revealed that the characteristic peaks in spectra of pure Flurbiprofen are also present in spectra of SDA’s. Drug found compatible with the excipients. The highest improvement in solubility and in-vitro drug release were observed in solid dispersion prepared with Poloxamer 188 (F14) by fusion method. The increased dissolution rate of drug from solid dispersion adsorbates may be due to surface tension lowering effect of polymer to the medium and increased wettability and dispersibility of drug. Hence, F14 Solid dispersion adsorbates with the Poloxamer carrier in 1:2 ratio considered as most satisfactory among all solid dispersion adsorbates.