Open AccessFormulation and Evaluation of Transdermal Patch of Blonanserin
Author(s) -
Daywin Patel,
Saurav M. Patel,
Sanjesh G. Rathi,
Shrenik K. Shah
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i02.011
Subject(s) - transdermal , xanthan gum , plasticizer , excipient , transdermal patch , compatibility (geochemistry) , solvent , polyvinyl alcohol , chromatography , polymer , materials science , natural polymers , chemistry , composite material , organic chemistry , pharmacology , rheology , medicine
The objective of the present study was to formulate and evaluate transdermal patch of Blonanserin. Blonanserin transdermal patcheswere prepared by solvent casting method using natural and synthetic polymer. Various plastisizer were screened along with polymers. Drug excipient compatibility studies concluded that the drug and excipient are compatible with each other. The prepared patches were evaluated for physico-chemical parameters to justify their suitability for transdermal use. Formulations containing Xanthan Gum with plasticizer propylene glycol gives best drug release in 8 hours. More than 90% drug release found after 8 hours in formulation F5. Hence F5 formulation is considered as optimized batch. F5 batch was found stable during stability study. Blonanserin transdermal patches were successfully prepared by solvent casting method using Xanthan Gum natural polymer.