Open AccessImpact of Curcumin on Nucleic Acids in Diethanolamine Induced Toxicity in Mus musculus
Author(s) -
Hetal Doctor,
Sanman Samova,
Ramtej J. Verma
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i02.004
Subject(s) - curcumin , nucleic acid , toxicity , diethanolamine , body weight , chemistry , antioxidant , pharmacology , in vivo , food science , toxicology , biochemistry , biology , microbiology and biotechnology , endocrinology , organic chemistry
Tremendous hike in the use of chemicals in every consumables worldwide, led researchers to investigate the effects of variousproducts and their ingredients that are being used in routine. Diethanolamine (DEA) is one such organic compound used in various industries and several personal care products that are being used daily. To evaluate DEA toxicity on nucleic acid content, Swiss strain male albino mice were chosen as animal model for in vivo experiments. Mice were exposed to DEA (110, 165, 330 mg/kg bodyweight/day) for 30 days. Animals were sorted into nine different groups, each containing 10 animals per group. In untreated controlgroups of animals no significant changes in nucleic acid content were noted whereas in DEA exposed animals, nucleic acid contentdecreased significantly (p<0.05) in a dose-dependent manner. However, more decrease were noted in high dose (330 mg/kg bodyweight/day) exposed animals as compared to other groups of animals. For the mitigation of the toxicity generated by DEA, curcumin, a miraculous antioxidant, which is an active component of turmeric was used. Curcumin (10, 20, 30 mg/kg body weight/day) was orally administered for 30 days along with the high dose of DEA. After completion of treatment, animals were humanly sacrificed and liver was quickly isolated for further biochemical evaluations. In animals exposed to curcumin for 30 days the nucleic acid content increased significantly (p<0.05) as compared to DEA-HD treated groups of animals. The effect was dose-dependent. The ameliorative effect of curcumin might be due to its high antioxidant potency.