Open AccessHow Effective is Curcumin in Prevention of Cancer
Author(s) -
Mercy Paul M,
A Alekhya,
L Krishnamurthy
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i02.001
Subject(s) - curcumin , curcuma , chemistry , bioavailability , zingiberaceae , dimethyl sulfoxide , liposome , rhizome , pharmacology , traditional medicine , biochemistry , biology , medicine , organic chemistry
The human physiology is a significant and a complex process, which is designed accordingly with multitude of functions. Phytochemicals are naturally occurring compounds found in plants, have modulating potential which is useful regarding chemoprevention. Curcumin (diferuloyl methane) is the dried ground rhizome of the perennial herb “Curcuma Longa” Linn, under the family of “Zingiberaceae”. It is readily soluble in ethanol or acetone, dimethyl sulfoxide (DMSO), glacial acetic acid, poorly soluble in water since it is lipophilic in nature. In India, the average intake of turmeric is reported to as high as 2.0-2.5 g/day (approx. up to 0.1g of curcumin) no adverse effects have been studied at the population level. Curcumin triggers multiple biological mechanisms in tumour environment at different stages. Curcumin act on different cancer types such as colorectal, prostate, pancreatic, skin, headneck squamous cell carcinoma, breast, brain and glioblastoma. Various formulations have been prepared to improve the bioavailability and solubility of curcumin which includes nanoparticles, liposomes, phospholipid complexes, structural analogs, cyclodextrins, nanogels, solid dispersions etc.,