Open AccessFormulation and Evaluation of Floating Tablets of Tofacitinib Citrate
Author(s) -
Sanjesh G. Rathi,
JayKumar G. Chaudhari
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.025
Subject(s) - guar gum , sodium bicarbonate , chromatography , drug , chemistry , tofacitinib , polymer , sodium citrate , sodium hyaluronate , methyl cellulose , nitrendipine , pharmacology , materials science , cellulose , medicine , calcium , food science , organic chemistry , rheumatoid arthritis , pathology
The present research work done with an objective of preparation and evaluation of floating tablets of Tofacitinib Citrate drug withHydroxy propylene methyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.