Open AccessA Review on Lipid Based Oral Drug Delivery Systems
Author(s) -
Suraj B. Pund
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.013
Subject(s) - bioavailability , drug , drug delivery , pharmacology , absorption (acoustics) , chemistry , solubility , biochemical engineering , medicine , materials science , organic chemistry , engineering , composite material
The main problem in oral drug formulations is low and erratic bioavailability, which is mainly due to poor aqueous solubility. This can lead to high inter- and intra-individual variability, lack of dose proportionality, and failure. Improving the bioavailability of drugs with such properties presents one of the greatest challenges in formulations. Oral lipid-based formulations are interesting considerable attention due to their ability to improve solubility, facilitate gastrointestinal absorption, and reduce or eliminate the effect of food on poor water absorption. soluble lipophilic drug and therefore increases bioavailability. This review describes recent findings on Potential Advantages of these Systems, Types of Lipid-Based Drug Delivery Systems, Guidelines for Design of Lipid-BasedFormulations, problems solved by LBDDS, Characterization of Lipid-Based Drug Delivery Systems, Applications of lipid-basedformulations, including traditional medicine (TM), new trends in LBDDS, Regulatory Aspects has also been examined in the currentrevision.