Open AccessFormulation and Evaluation of Sintered Gastroretentive Tablets of Pioglitazone
Author(s) -
E.Veena Rani
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.007
Subject(s) - carnauba wax , friability , materials science , sintering , guar gum , granulation , stearic acid , wax , composite material , melting point , paraffin wax , chemical engineering , polymer , chemistry , ethyl cellulose , food science , engineering
The aim of the present study is to prepare sintered gastroretentive tablets of Pioglitazone and to study the effect of sintering oninvitro dissolution study, hardness and friability. Sintering is defined as the process of compaction or formation of compact at atemperature below the melting point of solid constituent for the purpose of increasing its strength by bonding the particles together. EVA 1802, stearic acid, carnauba wax, and natural polymers like almond gum, xanthun gum, guar gum were used. The tablets were prepared by direct compression and wet granulation technique using PVP as binder and EVA, carnauba wax, stearic acid in different concentration of 10%, 15% were used in preparation. The prepared tablets were subjected to sintering at three differenttemperatures of 50, 60, 70°C for three different time periods of 1hr, 2hr, 3hrs in hot air oven. Precompression and post compressionparameters were performed. Results showed that the release rate of the drug was inversely related to the sintering temperature andtime of sintering. The optimum drug retardation occurred in the tablets at 70°C for 3hrs. increasing the temperature and time ofexposure to a particular temperature often decreases the release rate of the drug. In addition, the hardness of the sintered tabletswas increased with increasing sintering temperature and duration of sintering whereas friability of tablets was found to be decreasedwith increasing time. The optimized formulations F3(SA+CW+XG), F4(SA+CW+EVA) sintered at 70°C for 3hrs showed the maximumrelease of 70-80%. from the kinetic profile it shows that the drug release followed zero order and nonfickian diffusion mechanism.Thus, the formulations F3 and F4 was considered to be the best formulations among all the 6 formulations sintered at varioustemperature and various time periods. Hence it shows the suitability of EVA,SA,CW, natural polymers for preparing the sintered gastroretentive tablets of Pioglitazone.