Open AccessFormulation and Evaluation of Fluvastatin Loaded Solid Lipid Nanoparticles
Author(s) -
P. Tripura Sundari,
Gopu Akhila
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.006
Subject(s) - drug , zeta potential , pulmonary surfactant , nanocarriers , solid lipid nanoparticle , chemistry , entrapment , pharmacology , solubility , chromatography , peg ratio , particle size , drug carrier , nanoparticle , materials science , nanotechnology , medicine , biochemistry , organic chemistry , surgery , finance , economics
In the present work Fluvastatin was taken which is anti-hyper lipidemic drug used for chronic treatment. It belongs to BCS class-IIwhich means low soluble & high permeable drug. The current dosage regimen is 20-80mg for 2-3 times a day. The present work aims at reducing the dose of the drug by converting it into nanocarrier systems. For this purpose, SLN’s were prepared by employing Compritol as lipid, Soyalecithin as lipophilic surfactant, Tween-80/PEG-400 as hydrophilic surfactant systems. The prepared formulations were named as T1 to T4 with Tween-80 and P1 to P4 with PEG-400. All the prepared formulations are evaluated for drug content, entrapment efficiency and drug release studies. Among all the preparations best formulation was found to be P3 in terms of Drug content of 96.2%, Entrapment efficiency of 90.87% , Drug release of 61.0%, Particle size of 578nm with Zeta potential of -26mV. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release.