Open AccessComparison of Different Solubility Enhancement Techniques for Clopidogrel
Author(s) -
Degala. Vishwanayani,
P. Tripura Sundari
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.005
Subject(s) - solubility , cyclodextrin , solvent , drug , dispersion (optics) , peg ratio , materials science , polymer , chemistry , chromatography , chemical engineering , organic chemistry , pharmacology , medicine , physics , finance , optics , economics , engineering
The present study is aimed to formulate and evaluate various formulations to enhance the solubility of poorly aqueous soluble drug Clopidogrel. For this we have selected different techniques like solid dispersion, Nanosuspension and cyclodextrin complexes. As apart of it we prepared solid dispersions of drug employing PVPk30 and PEG 4000. Beta cyclodextrin complexes are prepared bykneading and solvent evaporation methods. Whereas nanosuspension are prepared by employing polaxomer as polymer. The prepared formulations were evaluated for drug Content and drug release studies.