Open AccessScreening of Biological Effectiveness of Endophytic Fungi Associated with Plectranthus amboinicus: A focus on Aspergillus terreus
Author(s) -
Tejaswini H.K,
M Jayashankar,
Mohammed Ali Ahmed Saeed
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v69i01.004
Subject(s) - aspergillus terreus , dpph , antimicrobial , antioxidant , plant use of endophytic fungi in defense , traditional medicine , minimum inhibitory concentration , food science , ethyl acetate , plectranthus , chemistry , biology , botany , microbiology and biotechnology , biochemistry , medicine , lamiaceae
Endophytic fungi produce a diverse range of bioactive molecules, which aids to produce a rich source of different types of medicines.The present study aims to evaluate the antimicrobial, antioxidant, and antidiabetic activity of fungal endophytes associated withedible leaves Plectranthus amboinicus (Indian borage). The results of preliminary screening of antibacterial activity showed inhibitionagainst all tested pathogens similarly, crude ethyl acetate extract of all the isolates in the secondary screening of antidiabetic activityshowed a good zone of inhibition with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The antioxidant activities were also determined by using the TPC, FRAP, and DPPH assay, which showed considerable variationsconcerning their positive control. The correlation among antioxidant assays indicated a strong correlation between TPC and DPPH.Also, the antidiabetic activity by alpha-amylase inhibition assay showed good inhibitory activity in different concentrations. Thus, the study suggested that endophytes from this edible plant could be potential source for the production of broad-spectrum antimicrobial, antioxidant, and antidiabetic compounds.