Open AccessChitosan – A Novel Biopolymer AS A Potential Drug Delivery Vehicle
Author(s) -
P Shlini,
Nidhi Mohan,
Shobha Mule
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v68i02.024
Subject(s) - chitosan , biopolymer , chitin , biocompatibility , drug delivery , chemistry , polysaccharide , glycosidic bond , chemical structure , biodegradation , chemical modification , combinatorial chemistry , organic chemistry , biochemistry , polymer , enzyme
Chitosan is a natural linear amino polysaccharide produced from the deacetylation of chitin obtained from crustaceans and insects.Chitosan structure consists of 2-acetamido-d-glucose and 2-amino-d-glucose units linked with glycosidic linkages. It is a versatilecompound due to presence of reactive amino and hydroxyl groups making it easily available for chemical reactions. Various functionalchitosan derivatives have been prepared using ionic interactions and other chemical modifications. Chitosan is known to exhibitexcellent properties such as biodegradability, biocompatibility, non-toxicity and easy absorption which led to significant researchtowards industrial, pharmaceutical and biomedical applications. This review discusses the importance and characteristics of chitosanand its derivatives by describing various aspects including biological properties, chemical properties, techniques of preparation andits applications.