Open AccessFormulation and Evaluation of Fast Dissolving Film of Losartan Potassium
Author(s) -
A Bhageerathy,
Sandhya Murali,
eny Sara Thomas,
Sigi Vasanthkumar,
Prasanth
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v68i01.036
Subject(s) - losartan potassium , dissolution , potassium , chemistry , chromatography , folding endurance , dissolution testing , solvent , losartan , in vivo , drug , materials science , pharmacology , medicine , first pass effect , biochemistry , angiotensin ii , organic chemistry , microbiology and biotechnology , receptor , biopharmaceutics classification system , biology
A total of nine formulations of fast dissolving films of Losartan Potassium were developed by solvent casting method using filmforming polymers such as HPMC E5, E15 and E50 and other film modifiers. The appearances of films were transparent, thin, flexible,elastic, smooth and transparent. The weight variation ranged between 16.14 ± 0.192 and 17.31 ± 0.313 and showed that there wasno significant difference in the weight of individual formulations. All the formulations showed more than 150 of folding endurance.The drug content was found to be in an acceptable range for all the formulations which indicated uniform distribution of drug. A rapiddissolution of all the film was observed by the dissolution test, in which above 90% of Losartan Potassium was released within 5 min. The formulation F1 showed maximum drug release (98.73) within 5 minutes. Based on the in vitro drug release, drug content and in vitro disintegration time it is found that F1 was selected as the best formulation. The formulations showed satisfactory physical stability at 40°C at 75 % RH. Losartan Potassium (LOSAR-25) is shown in Figure 4. From the results of comparative studies of marketed product and it found that F1 showed 98.73% release within 5 min and LOSAR 25 showed 90.76% release in 30 min. In vitro studies indicate that this potential drug delivery system has considerably good stability and release profile. Nevertheless, further in vivo studies are warranted to confirm these results.