Open AccessA Novel Approaches - Gastroretentive Microballoons Drug Delivery System
Author(s) -
Baochen Bai,
Sundaram Gunasekaran
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v68i01.029
Subject(s) - bioavailability , glass microsphere , drug delivery , microsphere , dosage form , drug , biomedical engineering , immediate release , materials science , nanotechnology , pharmacology , medicine , chemical engineering , engineering
Due to its potential to stay in the gastric region for a longer period of time, the gastro-retentive is one of the most promising oral drugdelivery systems. This increases the solubility of the drug, which improves bioavailability and reduces drug waste. To achieve thegastro-retentive property, numerous methods have been proposed. Microballoons are the most common form among them.Microballoons (hollow microspheres) have the ability to be a viable option for gastric retention. The microballoons drug deliverysystem is based on a non-effervescent system that comprises hollow spherical particles with no center and a size of less than 200micrometres. The microballoons drug delivery system has been shown to be more effective in regulating the rate of release of drugs with site-specific absorption. The floating Microballoons demonstrated gastro-retentive mediated release delivery with effective methods for increasing bioavailability, and they could be a promising solution for gastric retention. Optimized hollow microspheres could play a key role in novel drug delivery, especially in secure, targeted, and efficient in vivo delivery. They may be a promising approach for gastric retention, which would minimize variability in plasma drug concentrations. The review presents an insight in to recent advance methods of formulation, evaluation, polymers used in microballoons, applications of microballoons as gastroretentive drug delivery system which provide controlled release properties.