Open AccessComputational Repurposing Model of Curcumin as a Drug
Author(s) -
Ratna Roy,
Ratul Bhowmik,
Shatarupa Seth,
Snigdha Bhattacharyya,
Sounok Sengupta
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v68i01.026
Subject(s) - drug repositioning , repurposing , curcumin , drug , drug discovery , antiviral drug , medicine , disease , virtual screening , docking (animal) , virology , pharmacology , biology , bioinformatics , ecology , nursing , pathology
Viral diseases continue to be a public threat on a global scale day by day and the world is in a continuing battle with the novel deadlyviral Diseases and with no prompt medicines accessible the scourge brought about by the disease is expanding step by step. Theongoing need to develop new antiviral drugs with fewer side-effects and that are effective against viral pathogens has spurred the research community to invest in various drug discovery strategies, one of which is drug repurposing the methods of finding most promising existing compounds which has able to give best positive effects against viral infections. We present a docking?basedscreening using a quantum mechanical scoring of drug Curcumin with Proteins with PDB id’s 4B3V, 5LK0, 6BM8, 4QUZ, 6SJV, 1JLF,5EG7, 7K40 could display antiviral activity against Rubella, Hanta, Herpes, Noro, papilloma, HIV, Influenza, COVID19. Clearly, thesecompounds should be further evaluated in experimental assays and clinical trials to confirm their actual activity against the viraldisease. We hope that repurposing of the drug from our recommendation may contribute to the rational drug design against the above viruses.