Open AccessEvaluation of in- vitro Anti-inflammatory Potential of Grevillea robusta A. Cunn, EX R.BR. Leaves
Author(s) -
Jhuma Samanta,
Vijay Kumar
Publication year - 2021
Publication title -
international journal of pharmaceutical sciences review and research
Language(s) - English
Resource type - Journals
ISSN - 0976-044X
DOI - 10.47583/ijpsrr.2021.v68i01.020
Subject(s) - anti inflammatory , polyphenol , proteaceae , ethanol , botany , in vitro , traditional medicine , chemistry , horticulture , biology , antioxidant , biochemistry , medicine , pharmacology
Synthetic Non-steroidal anti-inflammatory drugs (NASAIDs) are the choice of drug for inflammation. NASAIDs caused severe sideeffects like hyperacidity, gastric ulcer and so on. To avoid the side effects of NASAIDs, there is an urgent need for searching newmolecule from natural origin. Present study is therefore aimed to explore Grevillea robusta A. Cunn, ex R.Br. Family proteaceae leavesfor anti-inflammatory activity. Microscopic measurement (fibre length and width), Ash values and extractive values of Grevillearobusta leaves were determined to set the pharmacognostic standards. Chemical constituents were evaluated through chemical tests. The Ethanol extract of Grevillea robusta leaves (GRLE)) were subjected to evaluate in-vitro anti-inflammatory activity through HRBC method and Heat induced haemolytic method. The leaves of Grevillea robusta showed significant anti-inflammatory activity. The Ethanol extract (GRLE) showed significant anti-inflammatory activities. GRLE was found to contain polyphenols as chemicalconstituents which was the basis of anti-inflammatory activity. On the basis of result we can conclude that Ethanol extract of leavesof Grevillea robusta has good anti-inflammatory activity. GRLE could be used for treatment of inflammation.