Open AccessThe Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta
Author(s) -
Abdulsatar A. Haji,
Omar A. M. Al-Habib
Publication year - 2021
Publication title -
technium biochemmed
Language(s) - English
Resource type - Journals
ISSN - 2734-7990
DOI - 10.47577/biochemmed.v2i1.3234
Subject(s) - taurine , chemistry , aorta , endocrinology , medicine , relaxation (psychology) , endothelium , biophysics , pharmacology , biology , biochemistry , amino acid
The current study included the relaxant effect of taurine on rat’s aortic rings and the mechanism behind this relaxation. Taurine produced a potent spasmolytic effect on aortic rings at concentrations from zero to 80 mM. The results of K+ channel subtypes using specific blockers indicated that the Kv channel has a considerable role in taurine-induced relaxation, while KATP has a limited role, Exposure of aortic rings to combinations of two K+ blockers showed that KCa, Kv, and KIR play important role in taurine mediated relaxation. The endothelium-derived hyperpolarizing factors used showed responses to a variable extent in taurine mediated relaxation; since NO and cGMP played a major role whereas PGS played a minor role in taurine mediated relaxation. Finally, the results also indicated that taurine-mediated relaxation is endothelium-dependent.