Open AccessSynthesis of silver nanocomposite hydrogels based on Poly (acrylic acid) and Poly (vinyl pyrrolidone) grafted onto Salep biopolymer and its use in drug release
Author(s) -
Ghasem Rezanejade Bardajee,
Hanieh Mostashfi,
Zari Hooshyar
Publication year - 2021
Publication title -
international journal of ayurvedic medicine
Language(s) - English
Resource type - Journals
ISSN - 0976-5921
DOI - 10.47552/ijam.v12i3.1949
Subject(s) - biocompatibility , biopolymer , nanocomposite , fourier transform infrared spectroscopy , self healing hydrogels , materials science , acrylic acid , nuclear chemistry , chemical engineering , polymer chemistry , drug delivery , chemistry , polymer , nanotechnology , composite material , copolymer , engineering , metallurgy
This study aimed to synthesize a silver nanocomposite hydrogel based on poly (acrylic acid) and poly (vinyl pyrrolidone) grafted onto salep biopolymer and its use in controlled drug release. Drug release is one of the medicine goals that have been happening in the different methods, such as injections, pills or sprays. The useful drug dose, has measured by the drug concentration in the blood system, in the specific time. Researches have shown, in above methods, at the first time there is a high concentration of drug in the blood and by passing the time, this concentration decreases, so for achieve the useful drug dose, more drug is needed which it usually causes the increasing of the drug side effects. Thus for preventing these side effects, controlled drug release is investigated in this research. To identify the synthesized hydrogel, Fourier transform infrared spectroscopy (FTIR, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and thermometric gravimetric analysis (TGA) were used. The results showed that the release of deferasirox from the silver nanocomposite hydrogel network is related to the pH of the environment. In addition, the biodegradability and biocompatibility of this system have led to its use in the pharmaceutical industry.