Open AccessImpact of lead acetate and sodium and potassium stearates on lipid peroxidation processes in the body of experimental animals
Author(s) -
Olha Ye. Fedoriv,
Alexandra Ye. Kopach,
N. A. Melnyk
Publication year - 2021
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.47470/0016-9900-2021-100-4-406-410
Subject(s) - lead acetate , chemistry , stearate , lipid peroxidation , toxicity , potassium , malondialdehyde , sodium , oral administration , lead poisoning , sodium acetate , biochemistry , zoology , food science , physiology , medicine , chromatography , antioxidant , organic chemistry , biology , psychiatry
. Given the significant prevalence of lead in the environment, research in this area has significant social and economic importance. Lead compounds are characterized by high toxicity and increased ability to cumulate in ecosystems, humans, and animals. Lead enters the human body with food, drinking water, atmospheric air, and smoking. Lead causes pathological changes in the nervous system, blood-forming organs, kidneys, etc. Materials and methods. The experiments were carried out on four groups of white female rats, each included seven animals, weighing 150-200 g. The first group of animals was a control. The second group consumed dechlorinated water from the city water supply, followed by lead acetate. The animals from the third and fourth groups drank the same water with sodium stearate and potassium stearate content in a dose of 1/250 LD50. After the 40th-day of the use of these waters, the animals were orally administered lead acetate at a dose of 7 mg/kg. The levels of lipid peroxidation biomarkers were studied by studying the content of diene conjugates (DC) and malondialdehyde (MDA) in blood serum, liver, and kidney homogenates. Results. The administration of 1/2 acetate LD50 to lead in experimental rats drinking water with stearates was accompanied by a significant increase in the DCs concentration and (MDA) in animals. Higher concentrations of LPO products were observed in the group of animals that consumed water from potassium stearate. Conclusions. 1. With the oral administration of lead acetate against the background of drinking water containing stearates at a dose of 1/250 LD50, an increase in lipid peroxidation indices was noted compared with the control group. 2. Higher concentrations of LPO products were observed in the group of animals consuming water from potassium stearate.