Open AccessChromato-mass spectrometric identification of asymmetric dimethylhydrazine and its derivatives in environmental objects and biological media in the population residing near the fall areas of separated rocket vehicles parts
Author(s) -
В. Б. Алексеев,
Т.С. Уланова,
Tatyana V. Nurislamova,
Н. А. Попова,
O. A. Mal'Tseva
Publication year - 2020
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 13
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.47470/0016-9900-2020-99-8-773-779
Subject(s) - population , rocket (weapon) , chemistry , mass spectrometry , environmental chemistry , rocket propellant , snow , dimethylhydrazine , chromatography , environmental science , environmental health , meteorology , geography , engineering , aeronautics , medicine , organic chemistry , propellant , colorectal cancer , cancer
Introduction. The issue of presence/absence of the consequences of technogenic space and rocket activity over the long period is on the agenda of the professional, social, and political communities, especially in regions were the certain territories have been appointed as the fall areas for the separated rocket vehicles parts, including the Republic of Altai.Aim of study. Identification of the chemical composition of snow samples, drinking water, and blood in the population residing in the fall areas of the separated rocket vehicle parts in the Republic of Altai.Material and methods. Identification of the chemical composition has been performed along with the quantitative determination of the content of N-nitrosamines in blood samples (n=50) in n the population who constantly live near to the fall areas of the separated rocket vehicles, as well snow samples (n=7), and drinking water (n=9). The samples were examined by a hybrid method using an Agilent gas chromatograph with a quadrupole mass spectrometric detector. In order to decrypt the results of the mass spectrometric analysis, we used the NIST Mass Spectrometry Data Library 08.L, WILEY275.L, PMW_TOX2.L., libraries of the United States Environmental Protection Agency, narcotic, herbal, toxic and contaminated substances. The quantitative determination of N-nitrosamines in the blood samples was performed by the method of chromatography-mass spectrometry.Results. During the library search, 94% of the studied blood samples in the population registered substances that can be identified as unsymmetric dimethylhydrazine and 6% of the samples contain its decomposition product N-nitrosodimethylamine. However, the probability of categorizing these impurities to the desired substances was of 4-26%. In the blood samples of residents in whom there were identified asymmetric dimethylhydrazine and N-NDMA by quantitative chromatography-mass spectrometric analysis, the tag (Alt+2) N-nitrosodimethylamine and N-nitrosodiethylamine was found in the concentration range of 0.00095-0.346 mg/dm3. In 100% of the studied drinking water samples, residual amounts of asymmetric dimethylhydrazine were identified with a low probability of matching the library mass spectrum of 12-33%.Conclusion. The conducted chromatography-mass spectrometry studies of snow samples, samples of the water, and blood of the population living near to the fall area of the separated rocket vehicle parts in the Republic of Altai allowed establishing the signs of residual quantities of dimethylhydrazine and N-nitrozodimethylamine.