Open AccessThe standard deviation of the red blood cells distribution width by volume as an assumed biomarker of chronic alcohol intoxication
Author(s) -
В. В. Шилов,
А. А. Вершинин,
G. E. Guseinov,
В. А. Лукин,
O. L. Markova
Publication year - 2020
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 13
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.47470/0016-9900-2020-99-6-645-648
Subject(s) - medicine , red blood cell distribution width , exacerbation , alcohol intoxication , biomarker , alcohol dependence , alcohol , physiology , poison control , injury prevention , emergency medicine , biochemistry , chemistry
. At present, Russia occupies one of the leading places in the world in ethanol consumption per capita. The actual and unsolved problem remains the diagnosis and prevention of chronic alcoholism. The definition of carbohydrate-deficient transferrin proposed by many authors has many drawbacks, in particular, a rather high cost, as well as a limited sensitivity of the index after two weeks from an episode of ethanol consumption. For this reason, it seems necessary to search for alternative biomarkers of chronic alcoholism. One of the applicants for the role of a marker of chronic alcohol intoxication is the Red blood cell Distribution Width - standard deviation (RDW-SD). The article contains the results of a study of changes in the standard deviation of the RDW-SD in the venous blood of patients with acute ethanol poisoning in cases with chronic alcohol intoxication.The aim of this work was to quantify the change in RDW-SD in patients with alcohol dependence (chronic alcohol intoxication) during periods of exacerbation (acute alcohol poisoning of moderate severity). Material and methods. The research materials were clinical blood tests of 245 patients on the first day after admission to the Department of Toxicology of the I.I. Dzanelidze. Research Institute of Emergency Medicine.Results. From the literature, it is known that the RDW-SD is largely associated with folic acid deficiency. Vitamin B9 deficiency can significantly increase the risk of cardiovascular disease due to the development of hyperhomocysteinemia in patients. Particular attention is required for patients aged 46-65 years, who have the highest level of RDW-SD with an increased risk of developing cardiovascular events. At the same time, the highest mortality rate in this age group from the reasons associated with the use of ethanol is noted, which gives reason to consider RDW-SD as one of the possible indices of the mortality risk. Conclusion. The possibility of using the magnitude of the change in the RDW-SD index as a biomarker of chronic alcohol intoxication in patients with a certain risk of cardiovascular complications is discussed with the rationale for the appointment of folic acid preparations as part of the complex treatment of chronic alcohol intoxication.