Biological effects of oxygen-enriched drinking water. Review. Part 1

Human life on Earth depends on the continuous availability of oxygen, but conditions for the entry of oxygen into the cells of the body change in time and space, easily broken, owing to what may develop hypoxia - a condition of oxygen starvation of tissues. The first part of the review provides information on the maintenance of oxygen homeostasis in cells, on the key component responsible for the regulation of the molecular response to hypoxia - the HIFs family of transcription factors (Hypoxia-Inducible Factors). It is indicated that it is possible to compensate for the lack of oxygen in the body by delivering it to cells and tissues with water and various oxygen cocktails. Data from experimental studies of the biological effect of oxygenated drinking water, as well as the results of studying the effects of oxygen-enriched drinking water with the participation of volunteers are presented. The issue of the formation of oxygen (free) radicals when drinking oxygen-enriched drinking water is considered. The second part of the review will provide data on the successful use of oxygen-rich water in domestic therapeutic and surgical practice in complex treatment in order to reduce the negative effect of hypoxia in patients with chronic heart failure and generalized peritonitis complicated by intestinal insufficiency syndrome; on the method of improving the supply of oxygen to the body using enteral oxygen therapy - oxygen cocktails - for diseases of the heart, lungs, bronchi and gastrointestinal tract, atopic dermatitis, placental insufficiency, as well as to improve physical and mental performance. The review draws specialist’s attention to the problem of the biological effect of oxygen-enriched drinking water, its insufficient knowledge and the possible yet unrealized potential in terms of preventing various diseases and maintaining optimal human health.