Open AccessClinical case of statin-induced myopathy in female patient with compensated hypothyroidism and unfavorable polymorphic variant of SLCO1B1*5 (c.521T>C)
Author(s) -
Liya A Lugovaya,
AUTHOR_ID,
Alexey A. Nekrasov,
Л Г Стронгин,
Т. А. Некрасова,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2021
Publication title -
kliničeskij razbor v obŝej medicine
Language(s) - English
Resource type - Journals
eISSN - 2782-5671
pISSN - 2713-2552
DOI - 10.47407/kr2021.2.5.00066
Subject(s) - slco1b1 , statin , myopathy , medicine , incidence (geometry) , endocrinology , bioinformatics , genetics , biology , gene , pharmacogenetics , genotype , physics , optics
Statin-associated muscle symptoms are one of the statin-induced side effects. The incidence of the condition is increased by the presence of associated risk factors, one of which is hypothyroidism. The paper reports clinical case of statin-associated muscle symptoms in patient with compensated hypothyroidism carrying a SLCO1B1 mutation. Optimal assessment and treatment algorithms are discussed.