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Impact of Age, Gender, post infection and post vaccination status on antibody response in COVID 19 patients
Author(s) -
Sidra Sadiq,
Maria Khan,
Tayyaba Sadiq,
Sheryar Orakzai,
Mirza Muhammad Dawood,
Najeeb Ul Haq,
Admin Admin
Publication year - 2022
Publication title -
journal of the pakistan medical association
Language(s) - English
Resource type - Journals
ISSN - 0030-9982
DOI - 10.47391/jpma.5309
Subject(s) - medicine , covid-19 , vaccination , antibody response , immunology , antibody , betacoronavirus , virology , outbreak , disease , infectious disease (medical specialty)
Objective: To evaluate severe acute respiratory syndrome coronavirus-2 spike protein antibodies against coronavirus disease-2019 in post-infection and post-vaccinated individuals.Method: The cross-sectional study was conducted June, 1 to July 31, 2021, at the Rehman Medical Institute, Peshawar, Pakistan, and comprised subjects of either gender in whom immunogenicity was checked 35 days post-vaccination and 90 days post-infection. Correlation with age and gender was checked. Specimens were collected and investigated for severe acute respiratory syndrome coronavirus-2 spike protein antibodies by consuming electro-chemiluminescence immunoassay. Data was analysed using SPSS 23.Results: Of the total 256 patients enrolled, 70(27.34%) were included; 49(69%) males and 21(29.6%) females. The overall mean age was 44±7.75 years. Among 30(42.8%) patients with positive polymerase chain reaction test, the mean time between positive the test and antibody screening was 90±30 days. Among the 40(57.2%) vaccinated individuals, the time between vaccination and antibody screening was 35±9.74 days. Overall, 68(97%) patients revealed robust positive findings to severe acute respiratory syndrome coronavirus-2 spike proteins antibodies >50IU/mL. Male subjects had significantly higher immunogenic response compared to females (p=0.001), and immunogenicity decreased with advancing age (p<0.001). Also, post-vaccinated patients’ antibody response was significant compared to post-infection patients’ response (p=0.001).Conclusion: Majority of the patients had significantly higher antibody titers against severe acute respiratory syndrome coronavirus-2 post-infection and post-vaccination. Males and younger individuals developed a significant humoral immunity compared to females and the elderly.Key Words: Antibodies, COVID-19, SARS-CoV-2, Vaccination.

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