Open AccessNeonatal haemolytic disease with co-existing Anti-D and Anti-C antibodies: an unusual experience
Author(s) -
Hafiza Mehreen Durrani,
Zubia Zaman,
Imran Raza,
Mohsin M. Jamali,
Ayesha Saleem,
Shabana Muzammil Ejaz
Publication year - 2022
Publication title -
journal of the pakistan medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.242
H-Index - 43
ISSN - 0030-9982
DOI - 10.47391/jpma.4564
Subject(s) - medicine , haemolytic disease , haemolysis , rh isoimmunization , antibody , jaundice , exchange transfusion , fetus , antigen , disease , pregnancy , rh blood group system , immunology , pediatrics , genetics , biology
Neonatal haemolytic disease in the new-born remains of prime importance for paediatricians due to high perinatal morbidity and mortality rates. The Rh antigen family comprises several different antigens, out of which, D antigen incompatibility is well known for causing severe haemolytic disease in the foetus. Although the current literature shows anomalous cases where coexisting non-D-Rh and D-Rh antigens are the causative agents, there is very little information regarding post-natal outcomes in neonates bearing two different incompatibilities simultaneously. Herein, we discuss an unusual case of anti-D as well as anti-C antibodies (non-D-Rh) in a male neonate born to a Rh-negative mother, who developed jaundice and haemolysis in post-natal life. The neonate underwent exchange transfusion and photo therapy due to raised serum bilirubin levels, supplemented with repeated blood transfusions, intravenous immunoglobulin therapy, and immunosuppressive therapy. He responded well to the management and was later discharged from the hospital. Long-term follow-up revealed no side-effects.